Albumin magnetic microspheres: a novel carrier for myelin basic protein.
作者： Haim Ovadia , Amy M. Carbone , Philip Y. Paterson
DOI: 10.1016/0022-1759(82)90245-9
关键词:
摘要: Myelin basic protein (MBP) of guinea pig origin was incorporated into magnetically responsive albumin microspheres. Protein-protein bonding and stabilization the GPMBP microspheres by heating at 120 degrees C did not adversely influence their capacity to bind anti-MBP antibodies or demonstrably alter encephalitogenic activity GPMBP. The magnetic properties particles fact that immunodeterminants some MBP fortuitously were distributed on exterior surfaces allowed a number experiments be carried out in Lewis rats for first time: (a) selective capture deletion particular subpopulation lymphoid cells responsible transfer experimental allergic encephalomyelitis (EAE) represented within lymph node (LNC) donor animals sensitized neutral antigen, (b) enhancement vivo uptake macrophages (M phi s) contained oil-induced peritoneal cell exudates exposed briefly microspheres, (c) preparation suspensions specifically enriched with respect MBP-containing M s.
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