Role of the solvent in optical resolution of trans-chrysanthemic acid via diastereomeric salt formation with (1R,2R)-1-(4-nitrophenyl)-2-dimethylaminopropane-1,3-diol

作者: Éva Kozsda-Kovács , György Miklós Keserü , Zsolt Böcskei , Ildikó Szilágyi , Kálmán Simon

DOI: 10.1039/A904682H

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摘要: Optical resolution of trans-chrysanthemic acid via diastereomeric salt formation with (1R,2R)-1-(4-nitrophenyl)-2-dimethylaminopropane-1,3-diol (DMAD) has been studied in different solvents. Ether type solvents containing MeOH were found to be preferred. The role was interpreted on the basis powder and single crystal X-ray diffraction DSC/TG measurements. We that incorporated into crystals less soluble diastereomer 1R DMAD a non-stochiometric amount postulated promote nucleation growth.

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