Role of receptor tyrosine kinases in gastric cancer: new targets for a selective therapy.
作者： JC Becker , C Müller-Tidow , H Serve , W Domschke , T Pohle
关键词:
摘要: Receptor tyrosine kinases (RTKs) such as the epidermal growth factor receptor family participate in several steps of tumor formation including proliferation and metastatic spread. Several known RTKs are upregulated gastric cancer being prime targets a tailored therapy. Only preliminary data exist, however, on use currently clinically available drugs trastuzumab, cetuximab, bevacizumab, gefitinib, erlotinib, imatinib setting cancer. Preclinical suggest potential benefit their use, especially combination with “conventional” cytostatic This review summarizes current knowledge about therapy well new approaches to optimize treatment success.
cnki.com.cn参考文章(91)
M D Pegram, R J Pietras, S B Howell, V R Chazin, B M Fendly, D J Slamon, Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells. Oncogene. ,vol. 9, pp. 1829- 1838 ,(1994)
Christopher J. Torrance, Peta E. Jackson, Elizabeth Montgomery, Kenneth W. Kinzler, Bert Vogelstein, Allan Wissner, Maria Nunes, Philip Frost, Carolyn M. Discafani, Combinatorial chemoprevention of intestinal neoplasia. Nature Medicine. ,vol. 6, pp. 1024- 1028 ,(2000) , 10.1038/79534
Harry N. Antoniades, Cha K. Chung, Expression of c-sis/platelet-derived growth factor B, insulin-like growth factor I, and transforming growth factor alpha messenger RNAs and their respective receptor messenger RNAs in primary human gastric carcinomas: in vivo studies with in situ hybridization and immunocytochemistry. Cancer Research. ,vol. 52, pp. 3453- 3459 ,(1992)
Zheng-Jun Song, Relationship between the expression of iNOS, VEGF, tumor angiogenesis and gastric cancer World Journal of Gastroenterology. ,vol. 8, pp. 591- 595 ,(2002) , 10.3748/WJG.V8.I4.591
Hua Zhang, Jian Wu, Lin Meng, Cheng-Chao Shou, Expression of vascular endothelial growth factor and its receptors KDR and Flt-1 in gastric cancer cells World Journal of Gastroenterology. ,vol. 8, pp. 994- 998 ,(2002) , 10.3748/WJG.V8.I6.994
Andrei Ougolkov, Kaname Yamashita, Vladimir Bilim, Yutaka Takahashi, Masayoshi Mai, Toshinari Minamoto, Abnormal expression of E-cadherin, β-catenin, and c-erbB-2 in advanced gastric cancer: Its association with liver metastasis International Journal of Colorectal Disease. ,vol. 18, pp. 160- 166 ,(2003) , 10.1007/S00384-002-0427-2
Mark G. Kris, Howard I. Scher, Vincent A. Miller, Maureen F. Zakowski, Francis M. Sirotnak, Efficacy of Cytotoxic Agents against Human Tumor Xenografts Is Markedly Enhanced By Coadministration of ZD1839 (Iressa), an Inhibitor of EGFR Tyrosine Kinase Clinical Cancer Research. ,vol. 6, pp. 4885- 4892 ,(2000)
Masakazu Yashiro, Kosei Hirakawa, Kazunori Nakazawa, Keratinocyte growth factor produced by gastric fibroblasts specifically stimulates proliferation of cancer cells from scirrhous gastric carcinoma. Cancer Research. ,vol. 63, pp. 8848- 8852 ,(2003)
L Taylorson, E Hersh, C Tang, S Meredith, A Ullrich, M Longhi, M E Berens, L Germain, D P Schwartz, J S Jacobs, L Chu, K P Hirth, J Tsai, H Chen, L K Shawver, G McMahon, E Mann, T J Powell, Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(trifluoromethyl)-phenyl]5-methylisoxazole-4-carboxamide. Clinical Cancer Research. ,vol. 3, pp. 1167- 1177 ,(1997)
Mark G. Kris, Adriana Haimovitz-Friedman, Yuhong She, Vincent A. Miller, F. M. Sirotnak, Valerie R. Rusch, Fei Lee, Jing Chen, The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 selectively potentiates radiation response of human tumors in nude mice, with a marked improvement in therapeutic index. Clinical Cancer Research. ,vol. 9, pp. 3773- 3778 ,(2003)