Structural properties of a monobrominated analog of 1,2-dipalmitoyl-sn-glycero-3-phosphorylcholine
作者： R.K. Lytz , J.C. Reinert , S.E. Church , H.H. Wickman
DOI: 10.1016/0009-3084(84)90033-1
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摘要: Abstract Hydrated multibilayers of1-palmitoyl-2-monobromopalmitoyl-sn-glycero-3-phosphoryl-choline (BrDPPC), where the 2-chain is brominated at either C-9 or C-10 position, have been studied by low and wide angle X-ray diffraction methods. Oriented unoriented samples were investigated. The long spacing was observed over temperature interval −15°C to 80°C. A monotonic increase from approx. 50 62 (28 wt. % H2O) occurred with decreasing temperature. BrDPPC showed no evidence of a sharp gel-to-liquid crystal phase transition. Wide scattering diffuse peak corresponding (4.5 A)−1. Differential scanning calorimetry measurements for hydrated liposomes (50 also transition (−40 ⪯ T 60°C). These results suggest amorphous (glass) state acylside chains BrDPPC. Monolayer film properties monobrominated stearic acid reflect chain disordering effect occurring upon midchain subsitution.
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