Prometheus: from legend to the real liver support therapy.

摘要: Background: A large number of patients develop liver disease that may evolve into progressive chronic failure. Artificial support systems (e.g., MARS and Prometheus) are considered in the framework steady increase who could possibly benefit from these blood purification devices. Albumin dialysis adsorption now two integrated concepts. The present know-how enabling us to appropriately modify several intrinsic characteristics adsorbents - e.g., their chemical nature, particle pore size distribution, as well a larger surface offered has helped better fine-tuning improve kinetics flow specifically for intended clinical application. These properties together with an improved biocompatibility have made possible development adsorptive techniques which clearances total removal rates target compound would be unthinkable conventional hemodialysis or hemofiltration. Several already available commercially treatment sepsis septic shock acute failure, but controlled studies end points still lacking.