The use Prometheus FPSA system in the treatment of acute liver failure: preliminary results.

摘要: Abstract The preliminary outcomes of patients with acute liver failure treated the Prometheus Fractionated Plasma Separation and Absorption (FPSA) system are presented herein. Patients methods procedures were performed in 13 (4, intoxication by Amanita phalloides; 4, unknown reason; 3, acetaminophen intoxication; 1, Wilson disease, insufficiency after hemihepatectomy owing to metastases colon adenocarcinoma). qualified for procedure according King’s College Hospital criteria. patients’ general status was assessed on basic GCS, UNOS, 4-grade encephalopathy classifications. 4008H Fresenius Medical Care unit. Results 29 mean duration 6.5 hours. There statistically significant reductions total bilirubin, ammonia, aminotransferase levels. In addition, corrected water, mineral, carbohydrate disorders. One patient did not require transplantation. Seven received transplants: three positive outcomes; two died due septicemia within 30 days perioperatively, one at 6 months OLT respiratory failure; one, hemorrhagic diathesis. Four receive a transplant because lack organ, no consent surgery, or neoplastic disease metastases. Conclusions FPSA-System an effective detoxication method failure. useful as symptomatic treatment before transplantation allowing longer wait graft.