Lipopolysaccharide levels are elevated in dengue virus infected patients and correlate with disease severity.

摘要: Abstract Background Although in the majority of cases dengue virus (DENV) infection results a self-limiting febrile disease, it can cause severe plasma leakage minority patients. The appearance indicates an increased permeability vascular wall. In this study we investigated if DENV lead to lipopolysaccharide (LPS) from intestine into blood patient, indicative intestinal mucosal barrier. Objectives aim was investigate LPS levels were elevated infected patients and these correlated with disease severity. Study design children determined using Limulus Amebocyte Lysate assay. To determine severity used 1997-WHO criteria, expert physician's judgement score that focused on particular. Furthermore, modulatory factors binding protein (LBP) sCD14, as well immune activation marker neopterin determined. Results We showed significantly compared healthy controls. had strongest correlation LPS. LBP, sCD14 Conclusion show evidence during infection. Moreover, between found, especially when terms leakage.