Hyperferritinaemia in Dengue Virus Infected Patients Is Associated with Immune Activation and Coagulation Disturbances

摘要: Background: During a dengue outbreak on the Caribbean island Aruba, highly elevated levels of ferritin were detected in virus infected patients. Ferritin is an acute-phase reactant and hyperferritinaemia hallmark diseases caused by extensive immune activation, such as haemophagocytic lymphohistiocytosis. The aim this study was to investigate whether patients associated with clinical markers activation coagulation disturbances. Methodology/Principal Findings: Levels ferritin, standard laboratory markers, sIL-2R, IL-18 fibrinolytic determined samples from uncomplicated Aruba. significantly increased compared other febrile illnesses. Moreover, occurrence viraemia. Hyperferritinaemia also thrombocytopenia, liver enzymes results validated cohort Brazil. In cytokine profiles determined. Increased Brazil disease severity pro-inflammatory profile. Conclusions/Significance: Altogether, we provide evidence that can be used marker discriminate between indicative for active resulting Therefore, recommend are monitored carefully.