Hyperferritinemia is a potential marker of chronic chikungunya: A retrospective study on the Island of Curaçao during the 2014-2015 outbreak.
作者： Fatih Anfasa , Lisette Provacia , Corine GeurtsvanKessel , Robert Wever , Izzy Gerstenbluth
DOI: 10.1016/J.JCV.2016.11.003
关键词: Viral load 、 Outbreak 、 Genotype 、 Virus 、 Serology 、 Chikungunya 、 Immunology 、 Biomarker (medicine) 、 Medicine 、 Virology 、 Chronic infection
摘要: Abstract Background Recently Chikungunya virus (CHIKV) outbreaks have been reported in the Carribean. There is no data regarding outbreak Curacao. In addition, to date there biomarker that could be used predict chronic infection. Objectives To characterize first CHIKV Curacao and identify potential biomarkers for Study design A serological test quantitative polymerase chain reaction (qPCR) were on samples collected confirm Subsequently, six with high viral load selected phylogenetic analysis. Furthermore we investigated association of macrophage-related during infection arthralgia/arthritis. Results 116 patients diagnosed based ELISA 77% tested positive by qPCR. Phylogenetic analysis showed an Asian genotype was cause outbreak. Elevated levels ferritin CRP significantly associated viraemia. elevated arthralgia. Conclusions The results presence time. Moreover, found between
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