Fibulin-3 is associated with tumour progression and a poor prognosis in nasopharyngeal carcinomas and inhibits cell migration and invasion via suppressed AKT activity.

摘要: Nasopharyngeal carcinoma (NPC) is known for its highly metastatic character. Recent advances in diagnosis and treatment have not improved the high mortality rate that attributable to early metastasis. Although several biomarkers correlate with metastasis prognosis, molecular mechanisms of NPC development progression remain unclear. We demonstrate comprehensively fibulin-3 down-regulated NPC. Loss expression significantly correlated advanced tumour lymph node-metastasis stages, indicates a poor 5-year survival rate. Functionally, has ability suppress cell migration invasion cancer cells by decreasing activity phospho-AKT. Conversely, depletion fibulin-3-mediated siRNAs may elevate phospho-AKT enhance migrate invade. Consistent this negative association between phospho-AKT, their levels are inversely specimens immunohistochemical analysis. Thus, lower an important indicator survival. It also contribute new therapeutic strategies block PI3K/AKT pathway cells.