EFEMP1 promotes the migration and invasion of osteosarcoma via MMP-2 with induction by AEG-1 via NF-κB signaling pathway

摘要: // Zhuo Wang 1 ,* , Chuang-Jie Cao Lei-Lei Huang Zun-Fu Ke Can-Jiao Luo Zhong-Wei Lin 2 Fen Yuan-Qi Zhang 3 and Lian-Tang Department of Pathology, The First Affiliated Hospital Sun Yat-sen University, Guangzhou, China Cardiology, Guangdong Pharmaceutical Vascular Surgery, Medical College, Zhanjiang, * These authors have contributed equally to this work Correspondence to: Wang, email: Keywords : osteosarcoma, AEG-1, EFEMP1, MMP-2, NF-κB Received January 04, 2015 Accepted March 03, 2014 Published 29, Abstract role epidermal growth factor-containing fibulin-like extracellular matrix protein (EFEMP1) in osteosarcoma remains unknown. Then applying EFEMP1 siRNA, plasmids transfection adding purified human cell lines, using immunohistochemistry on 113 tissues, demonstrated that was a poor prognostic indicator osteosarcoma; specifically upregulated associated with invasion metastasis vitro vivo . At the same time, we found direct regulatory effect MMP-2. Moreover, firstly marked induction by oncogenic AEG-1. And expression inhibited selective inhibitor (PDTC) cells. thought pathways might be one effective ways which induced Thus, suggested played part as mediator between AEG-1 signaling pathway an important process. In summary, invasion, prognosis patients. indirectly enhance providing potential explanation for metastasis.