Overexpression of AEG-1 in renal cell carcinoma and its correlation with tumor nuclear grade and progression.

摘要: UNLABELLED The study was aimed at detecting the expression of a newly found oncogene, astrocyte elevated gene-1 (AEG-1), in renal cell carcinoma (RCC) and its correlation with histopathologic features survival patients. Real-time reverse transcription-PCR Western blot showed markedly higher AEG-1 8 cases RCC tissue compared paired normal from same patient. level also increased four lines contrast tubular epithelial human kidney cells 2 (HK-2) both mRNA protein levels. Furthermore, immunohistochemistry analysis highly expressed 96 102 (94.1%) paraffin-embedded archival tissue. Statistical significant tumor grade (P while high AEG-1expression group 60.94m. Our results suggest that is overexpressed plays an important role differentiation progression. High closely associated poor prognosis. KEYWORDS Astrocyte gene-1, AEG-1, carcinoma,