Astrocyte elevated gene-1: recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration.

作者: Luni Emdad , Devanand Sarkar , Zao-Zhong Su , Seok-Geun Lee , Dong-Chul Kang

DOI: 10.1016/J.PHARMTHERA.2007.01.010

关键词:

摘要: Tumor progression and metastasis are complex processes involving intricate interplay among multiple gene products. Astrocyte elevated (AEG)-1 was cloned as an human immunodeficiency virus (HIV)-1-inducible tumor necrosis factor-alpha (TNF-alpha)-inducible transcript in primary fetal astrocytes (PHFA) by a rapid subtraction hybridization approach. AEG-1 down-regulates the expression of glutamate transporter EAAT2; thus, it is implicated glutamate-induced excitotoxic damage to neurons evident HIV-associated neurodegeneration. Interestingly, subsets breast cancer, glioblastoma multiforme melanoma cells, cooperates with Ha-ras augment transformed phenotype normal immortal cells. Moreover, overexpressed >95% malignant glioma samples when compared brain. Overexpression increases siRNA inhibition decreases migration invasion respectively. contains lung-homing domain facilitating lungs. These findings indicate that might play pivotal role pathogenesis, diverse cancers. Our recent observations exerts its effects activating nuclear factor kappa B (NF-kappaB) pathway downstream target plays important Ha-ras-mediated tumorigenesis. provocative intensifying interest crucial regulator potential mediator In this review, we discuss cloning, structure function(s) provide insights into actions intriguing properties molecule.

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