Genomic imprints as a model for the analysis of epigenetic stability during assisted reproductive technologies.

作者: Michelle M Denomme , Mellissa R W Mann

DOI: 10.1530/REP-12-0237

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摘要: Gamete and early embryo development are important stages when genome-scale epigenetic transitions orchestrated. The apparent lack of remodeling differential imprinted DNA methylation during preimplantation has lead to the argument that disruption by assisted reproductive technologies (ARTs) is restricted genes. We contend aberrant arising from reproduction or infertility may be an indicator more global instability. Here, we review current literature on effects ARTs, including ovarian stimulation, in vitro oocyte maturation, cryopreservation, IVF, ICSI, culture, genomic imprinting as a model for evaluating stability. Undoubtedly, relationship between impaired fertility, stability unquestionably complex. What clear future studies need directed at determining molecular cellular mechanisms giving rise errors.

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