Predictors of abdominal aortic calcification progression in patients with chronic kidney disease without hemodialysis

摘要: Abstract Background and aims Abdominal aortic calcification (AAC) is an important predictor of cardiovascular mortality in patients with chronic kidney disease (CKD). However, little known regarding AAC progression these patients. This study aimed to identify risk factors associated CKD without hemodialysis. Methods We recruited 141 asymptomatic hemodialysis [median estimated glomerular filtration rate (eGFR), 40.3 mL/min/1.73 m 2 ] evaluated the abdominal index (ACI) over 3 years. To contributing ACI progression, associations between baseline clinical characteristics annual change for each category were analyzed. The (ΔACI/year) was calculated as follows: (second ACI − first ACI)/duration two evaluations. Results Median ΔACI/year values significantly increased advanced stages (0.73%, 0.87%, 2.24%/year G1-2, G3, G4-5, respectively; p trend = 0.041). only independent factor mild moderate (G1-3, eGFR ≥ 30 mL/min/1.73 m ) pulse pressure level (β = 0.258, p = 0.012). In contrast, parathyroid hormone (PTH) correlated (β = 0.426, p = 0.007) among (G4-5, eGFR  ). Conclusions suggests that accelerated CKD. addition, measuring PTH useful evaluate both bone turnover