Impact of Renal Functional/Morphological Dynamics on the Calcification of Coronary and Abdominal Arteries in Patients with Chronic Kidney Disease
作者： Takeo Ichii , Ryota Morimoto , Takahiro Okumura , Hideki Ishii , Yosuke Tatami
DOI: 10.5551/JAT.39271
关键词:
摘要: Aim Fast-progressing vascular calcification (VC) is accompanied by renal atrophy and functional deterioration along with atherosclerosis in patients chronic kidney disease (CKD). However, the relationship between VC progression and/or morphological changes remains unclear. Methods We included 70 asymptomatic CKD without hemodialysis our study. To identify temporal variations, coronary artery score (CACS), abdominal aortic index (ACI), parenchymal volume (RPVI) were determined via spiral computed tomography scans taken during investigated significant factors related to annualized variations of CACS (ΔCACS/y) ACI (ΔACI/y). Results During follow-up period (4.6 years), median values [in Agatston units (AU)] increased from 40.2 113.3 AU (p=0.053) 13.2 21.7% (p=0.036), respectively. Multivariate analysis revealed that at baseline (p＜0.001) diabetes mellitus (DM) status (p=0.037) for ΔCACS/y (p=0.017) hypertension (HT) (p= 0.046) ΔACI/y independent predictors. Furthermore, RPVI variation was significantly both (R=-0.565, p＜0.001, R=-0.289, p=0.015, respectively). On other hand, contributions estimated glomerular filtration rate (eGFR) eGFR not confirmed. Conclusion The degree baseline, DM, HT, volume, but eGFR, had a strong impact on CKD.
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