Calcification of coronary arteries and abdominal aorta in relation to traditional and novel risk factors of atherosclerosis in hemodialysis patients

摘要: Background: Process of accelerated atherosclerosis specific for uremia increases cardiovascular risk in patients with chronic kidney disease (CKD) and may be influenced by the different structure arteries. The study assesses influence traditional novel factors on calcification coronary arteries (CAC) abdominal aorta (AAC) hemodialysis (HD). Methods: CAC AAC were assessed CT 104 prevalent adult HD 14 apparently healthy subjects normal function (control group). Mineral metabolism parameters, plasma levels FGF-23, MGP, osteoprotegerin, osteopontin, fetuin-A, CRP, IL-6 TNF-α measured. Results: (calcification score ≥ 1) found 76 (73.1%) 83 (79.8%) respectively, more frequent than control group. In 7 no detected. frequency severity calcifications increased age. Both frequently detected diabetics (OR = 17.37 13.00, respectively). was significantly greater males. scores correlated pack-years smoking osteoprotegrin levels. However independent contribution osteoprotegerin not confirmed multiple regression analysis. Age 1.13) vintage 1.14) factor favoring occurrence CAC; while age 1.20) only predictor HD. Conclusions: 1. precedes patients. 2. exposition to uremic milieu systemic microinflammation has deteriorative effect AAC.