The effect of fundoplication on proliferative and anti-apoptotic activity of esophageal mucosa in gastroesophageal reflux disease: 4-year follow-up study
作者： Tuomo RANTANEN , Niku OKSALA , Teemu HONKANEN , Jari RÄSÄNEN , Eero SIHVO
DOI: 10.1111/J.1751-2980.2011.00508.X
关键词:
摘要: OBJECTIVE: The capacity of fundoplication to prevent esophageal adenocarcinoma is controversial. Development cancer associated with proliferation and anti-apoptosis, for which little data exist as their response fundoplication. Therefore, we wanted clarify the effect on magnitude Ki-67 B-cell lymphoma 2 (Bcl-2) during 48 months follow up. METHODS: Bcl-2 were assessed quantitatively from biopsies esophagogastric junction (EGJ) distal proximal esophagus 20 patients gastroesophageal reflux disease (GERD) treated by An upper gastrointestinal endoscopy was performed preoperatively postoperatively at 6 16 patients, respectively. compared those 7 controls. RESULTS: Compared preoperative level, elevated in (P = 0.012) (P = 0.007) months. control values, lower EGJ (P = 0.037) (P = 0.003) higher (P = 0.002). (P = 0.038). Correlations between positive (P > 0.001) (P = 0.001) (P = 0.013). CONCLUSION: Proliferative activity after increased long-term up despite a normal fundic wrap objective healing GERD.
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