Mir-152 inhibits cell proliferation and colony formation of CD133(+) liver cancer stem cells by targeting KIT.
作者： Haili Huang , Min Hu , Peng Li , Caijie Lu , Mingyi Li
DOI: 10.1007/S13277-014-2719-X
关键词:
摘要: miR152 is involved in diverse biological functions and development of disease. This study investigates the role mir-152 cell proliferation colony formation liver cancer stem cells. We show that exogenous overexpression suppresses CD133(+) hep3B also KIT a direct target miR-152 downregulates protein expression by directly binding to 3' untranslated region KIT. Downregulation specific siRNAs inhibits cells, which similar inhibitory effects miR-152. Moreover, compromises on formation. Our findings suggest cells targeting
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