Lymphocyte response to tetanus toxin T-cell epitopes: effects of tetanus vaccination and concurrent malaria prophylaxis.

摘要: Synthesized T-cell epitopes of tetanus toxin are universally immunogenic and serve to enhance immune response when they used as vaccine carriers B-cell epitopes. The immunogenicity the P2, P30, P2P30 whole toxoid (TT) was evaluated by in vitro proliferation assay lymphocytes from men with no history vaccination who were enrolled a malaria prophylaxis trial. enhancement (Td) possible antagonism antimalarial drugs, measured pre- post-Td comparisons within between immunized groups (primaquine, chloroquine, placebo) nonimmunized control group. Constructs demonstrated low relative TT all groups. Relative both its own baseline, primaquine group distinct demonstrating significantly increased against three subunits at high (30 microg ml(-1)) (3 concentrations. Immunization elicited responses placebo chloroquine only construct. Despite these significant changes, concentration 0.1 stimulated 7-10 times over that induced greatest constructs.