摘要: Bioregulators are naturally occurring organic compounds that regulate diverse cellular processes. Unlike traditional disease-causing biowarfare agents take hours or days to act, many bioregulators act within minutes of administration. If exploited for the purpose bioterrorism, they could potentially cause profound physiologic effects. Other effects may be more subtle. The main groups discussed cytokines; eicosanoids, neurotransmitters, hormones, and proteolytic enzymes. Because advances continually being made in their development, should considered as weapons with increasing bioterrorism potential.
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sci-hub.se 参考文章(67)
P. Renard, M. Raes, The proinflammatory transcription factor NFκB: a potential target for novel therapeutical strategies Cell Biology and Toxicology. ,vol. 15, pp. 341- 344 ,(1999) , 10.1023/A:1007652414175
Gary J Bennett, Update on the Neurophysiology of Pain Transmission and Modulation: Focus on the NMDA-Receptor Journal of Pain and Symptom Management. ,vol. 19, pp. 2- 6 ,(2000) , 10.1016/S0885-3924(99)00120-7
Satoshi Nanzaki, Shigeyuki Sasaki, Osamu Kemmotsu, Satoshi Gando, Significant Correlations between Tissue Factor and Thrombin Markers in Trauma and Septic Patients with Disseminated Intravascular Coagulation Thrombosis and Haemostasis. ,vol. 79, pp. 1111- 1115 ,(1998) , 10.1055/S-0037-1615025
Sylvie Hermouet, Isabelle Corre, Eric Lippert, Interleukin-8 and other agonists of Gi2 proteins: autocrine paracrine growth factors for human hematopoietic progenitors acting in synergy with colony stimulating factors. Leukemia & Lymphoma. ,vol. 38, pp. 39- 48 ,(2000) , 10.3109/10428190009060317
Kenneth A. Roebuck, Laura R. Carpenter, Venkatesh Lakshminarayanan, Scott M. Page, James N. Moy, Larry L. Thomas, Stimulus-specific regulation of chemokine expression involves differential activation of the redox-responsive transcription factors AP-1 and NF-kappaB. Journal of Leukocyte Biology. ,vol. 65, pp. 291- 298 ,(1999) , 10.1002/JLB.65.3.291
D. R. Franz, Clinical recognition and management of patients exposed to biological warfare agents JAMA: The Journal of the American Medical Association. ,vol. 278, pp. 399- 411 ,(1997) , 10.1001/JAMA.278.5.399
K A Krown, M T Page, C Nguyen, D Zechner, V Gutierrez, K L Comstock, C C Glembotski, P J Quintana, R A Sabbadini, Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death. Journal of Clinical Investigation. ,vol. 98, pp. 2854- 2865 ,(1996) , 10.1172/JCI119114
Philip Padrid, Raoul Wolf, Nilda M. Munoz, Stephen Spaethe, Thomas Finucane, Julian Solway, Alan R. Leff, Augmented Muscarinic Responsiveness Caused by 5-Lipoxygenase Products Secreted from Alveolar Macrophages in Isolated-perfused Rat Lung The American review of respiratory disease. ,vol. 147, pp. 1514- 1520 ,(1993) , 10.1164/AJRCCM/147.6_PT_1.1514
L.A Laitinen, T Haahtela, V Vilkka, T.H Lee, B.W Spur, Leukotriene E4 and granulocytic infiltration into asthmatic airways The Lancet. ,vol. 341, pp. 989- 990 ,(1993) , 10.1016/0140-6736(93)91073-U
Kari J. Pulkki, Cytokines and Cardiomyocyte Death Annals of Medicine. ,vol. 29, pp. 339- 343 ,(1997) , 10.3109/07853899708999358