Curcumin protects neuronal cells against status-epilepticus-induced hippocampal damage through induction of autophagy and inhibition of necroptosis

摘要: Status epilepticus, the most severe form of epilepsy, is characterized by progressive functional and structural damage in hippocampus, ultimately leading to development clinical appearance spontaneous, recurrent seizures. Although pathogenesis underlying epileptogenesis processes remains unclear, a substantial body evidence has shown that status epilepticus acts as an important initial factor triggering epileptogenesis. Notably, besides classical cell death mechanisms such apoptosis necrosis, 2 novel regulators fate known necroptosis autophagy, are demonstrated be involved neuronal various neurodegenerative neuropsychiatric disorders. However, whether autophagy play role post-status-epilepticus rat hippocampus other epilepsy deserves further research effort. In addition, needed determine compounds from traditional Chinese herbs possess antiepileptic effects through modulation autophagy. this study, we found curcumin, polyphenolic phytochemical extracted Curcuma longa plant, protects cells against status-epilepticus-induced hippocampal lithium-pilocarpine-induced model induction inhibition necroptosis.