Necroptosis: an emerging form of programmed cell death.
作者： Wei Wu , Peng Liu , Jianyong Li
DOI: 10.1016/J.CRITREVONC.2011.08.004
关键词:
摘要: Necrosis plays an important role in multiple physiological and pathological processes. Recently, a relatively new form of necrosis has been characterized as "necroptosis". Morphologically, necroptosis exhibits the features necrosis; however, unique signaling pathway that requires involvement receptor interaction protein kinase 1 3 (RIP1 RIP3) can be specifically inhibited by necrostatins. Necroptosis found to contribute regulation immune system, cancer development well cellular responses stresses. In this review, we will summarize pathway, biological effects significance specific programmed cell death.
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