Neural transplantation cannula and microinjector system: experimental and clinical experience. Technical note.
作者： Ivar Mendez , Murray Hong , Stephen Smith , Alain Dagher , Jacques Desrosiers
DOI: 10.3171/JNS.2000.92.3.0493
关键词:
摘要: The authors present a simple, reliable, and safe system for performing neural transplantation in the human brain. device consists of cannula microinjector that has been specifically designed to reduce implantation-related trauma maximize number graft deposits per injection. was evaluated first an experimental rat model Parkinson's disease (PD). Animals which with this had performed showed excellent survival minimal Following stage, were used eight patients PD enrolled Halifax Neural Transplantation Program who received bilateral putaminal transplants fetal ventral mesencephalic tissue. A total 16 operations 64 trajectories patients, there no intraoperative or perioperative complications. Magnetic resonance imaging studies obtained 24 hours after surgery revealed evidence tissue damage hemorrhage. Transplant confirmed by fluorodopa positron emission tomography scans 6 12 months surgery. As procedures treatment neurological conditions evolve, ability deliver viable grafts safely will become critically important. presented here proved be value maximizing while minimizing host
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