Neural grafting in Parkinson's disease: unraveling the mechanisms underlying graft-induced dyskinesia
作者： Emma L Lane , Anders Björklund , Stephen B Dunnett , Christian Winkler , None
DOI: 10.1016/S0079-6123(10)84015-4
关键词:
摘要: The development of neural transplantation as a treatment for Parkinson’s disease has been compromised by lack functional efficacy and the appearance transplant-induced motor side-effects in some patients. Since first reports these graft-induced dyskinesias (GID), realization their impact on progress field, great deal experimental work performed to determine underlying cause(s) this problematic side-effect. In review we describe clinical phenomenon GID, explore different representations GID rodent models, examine various hypotheses that have postulated be cause. Based available preclinical data outline strategies avoid future trials using fetal cell transplants or preparations derived from stem cells.
elsevier.com
sci-hub.se 参考文章(65)
M. Angela Cenci-Nilsson, Peter Hagell, Dyskinesias and Neural Grafting in Parkinson's Disease Springer, Boston, MA. pp. 184- 224 ,(2006) , 10.1007/0-387-32823-2_10
C. Warren Olanow, Jean-Michel Gracies, Christopher G. Goetz, A. Jon Stoessl, Thomas Freeman, Jeffrey H. Kordower, James Godbold, Jose A. Obeso, Clinical pattern and risk factors for dyskinesias following fetal nigral transplantation in Parkinson's disease: a double blind video-based analysis. Movement Disorders. ,vol. 24, pp. 336- 343 ,(2009) , 10.1002/MDS.22208
Paola Piccini, David J. Brooks, Anders Björklund, Roger N. Gunn, Paul M. Grasby, Ornella Rimoldi, Patrik Brundin, Peter Hagell, Stig Rehncrona, Håkan Widner, Olle Lindvall, Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient Nature Neuroscience. ,vol. 2, pp. 1137- 1140 ,(1999) , 10.1038/16060
Christian Winkler, Deniz Kirik, Anders Björklund, Stephen B. Dunnett, Transplantation in the rat model of Parkinson's disease: ectopic versus homotopic graft placement. Progress in Brain Research. ,vol. 127, pp. 233- 265 ,(2000) , 10.1016/S0079-6123(00)27012-X
Christian Winkler, Deniz Kirik, Anders Björklund, M.Angela Cenci, L-DOPA-induced dyskinesia in the intrastriatal 6-hydroxydopamine model of parkinson's disease: relation to motor and cellular parameters of nigrostriatal function. Neurobiology of Disease. ,vol. 10, pp. 165- 186 ,(2002) , 10.1006/NBDI.2002.0499
Ivar Mendez, Murray Hong, Stephen Smith, Alain Dagher, Jacques Desrosiers, Neural transplantation cannula and microinjector system: experimental and clinical experience. Technical note. Journal of Neurosurgery. ,vol. 92, pp. 493- 499 ,(2000) , 10.3171/JNS.2000.92.3.0493
Christopher J. Schmidt, Walter Lovenberg, In vitro demonstration of dopamine uptake by neostriatal serotonergic neurons of the rat Neuroscience Letters. ,vol. 59, pp. 9- 14 ,(1985) , 10.1016/0304-3940(85)90207-1
Lachlan Thompson, Perrine Barraud, Elin Andersson, Deniz Kirik, Anders Björklund, Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections. The Journal of Neuroscience. ,vol. 25, pp. 6467- 6477 ,(2005) , 10.1523/JNEUROSCI.1676-05.2005
Paola Piccini, Olle Lindvall, Anders Bj�rklund, Patrik Brundin, Peter Hagell, Roberto Ceravolo, Wolfgang Oertel, Niall Quinn, Michael Samuel, Stig Rehncrona, H�kan Widner, David J. Brooks, Delayed recovery of movement-related cortical function in Parkinson's disease after striatal dopaminergic grafts Annals of Neurology. ,vol. 48, pp. 689- 695 ,(2000) , 10.1002/1531-8249(200011)48:5<689::AID-ANA1>3.0.CO;2-N
E.M. Torres, E. Dowd, S.B. Dunnett, Recovery of functional deficits following early donor age ventral mesencephalic grafts in a rat model of Parkinson's disease Neuroscience. ,vol. 154, pp. 631- 640 ,(2008) , 10.1016/J.NEUROSCIENCE.2008.03.048