Skilled motor control for the preclinical assessment of functional deficits and recovery following nigral and striatal cell transplantation.

摘要: Neural transplantation holds the promise for restoring behavioral function following brain injury. Substantial evidence indicates that fetal neurons transplanted to adult survive and incorporate into remaining neural tissue produce positive effects. A yet-unanswered question is whether integration of new can restore complex circuits connect neocortex, basal ganglia, brainstem, functions are mediated by these circuits. This chapter describes skilled reaching task, a task requires transport arm hand grasp food item withdrawal place in mouth eating. It movement readily expressed rodents fundamental both nonhuman primates humans. Methods analyzing have been developed preclinical rodent mouse models Parkinson's disease Huntington's generalizable humans with those clinical disorders. suggested provides motor benchmark assessing restoration produced transplantation.