Developmental patterns of aluminum and five essential mineral elements in the central nervous system of the fetal and infant guinea pig

摘要: Al is found in the developing conceptus, but little information available concerning its tissue distribution and changes concentration with age. Because has affinity for many of same biological ligands as essential mineral cations Ca, Mg, Zn, Fe, Mn, we hypothesized that might show a pattern developmental concentrations was similar to one or more these elements brain, major target toxicity. Concentrations Al, Mn were measured spinal cord, brainstem, cerebellum, forebrain guinea pig fetuses on gestation day (GD) 30 45, at birth, postnatal (PND) 3, 6, 12. Dams fed commercial chow, which contained 47 μg Al/g. Tissue electrothermal atomic absorption spectrophotometry (ETAAS), other inductively coupled axial plasma spectroscopy (ICAP-AES). brain regions highest decreased during late lactation. did not marked increases regional final third Zn. In contrast Fe accumulate placenta. only element higher cord than any birth. summary, follow examined this study.