Calcium disodium edetate enhances type A monoamine oxidase activity in monkey brain
作者： Toru Egashira , Kumiko Sakai , Mami Sakurai , Fusako Takayama
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摘要: The effects of metal chelators on monoamine oxidase (MAO) isozymes, MAO-A and MAO-B, in monkey brain mitochondria were investigated vitro. activity increased to about 40% with 0.1 µM calcium disodium edetate (CaNa2EDTA) using serotonin as a substrate, this activation was proportional the concentration CaNa2EDTA. On other hand, activities decreased gradually an increasing o-phenanthroline diethyldithiocarbamic acid, but these had no effect MAO-B brain. by CaNa2EDTA reversible. did not activate both rat mitochondria. Zn Fe ions found potently inhibited activity, inhibit either or These results indicate that activating action result chelating contained also possibility may regulate physiologically level norepinephrine content inhibiting activity.
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