Kainate receptors: a novel mechanism in paradoxical (REM) sleep generation.

摘要: Application of kainate to the peri-locus coeruleus alpha (peri-LC alpha) resulted in a marked increase paradoxical sleep (PS). This effect was completely blocked by specific non-NMDA receptor antagonists, but not selective NMDA antagonists. Kainate 10 times more potent than AMPA, and their site action confined peri-LC alpha. study is first show that excitatory amino acids play an important role PS generation via activation receptors which are located mediodorsal pontine tegmentum.