Cancer Drug Target Identification by SAGE, LongSAGE and Digital Karyotyping
作者： Heiko Hermeking
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摘要: Activated oncogenes are required for the initiation and maintenance of cancer cell phenotype, and, therefore, represent attractive therapeutic targets. Specific inhibition oncogene products was recently approved treatment. Oncogene activation often results from genomic amplification. The SAGE (serial analysis gene expression) method has been adapted to alterations, including amplifications. As a first step in this direction, LongSAGE, which allows one localize differentially expressed tags/mRNAs human genome, devised. Subsequently, LongSAGE protocol quantitative copy-number changes DNA. This new method, named Digital Karyotyping, identifies amplifications at an unprecedented resolution. In chapter SAGE-based quantification expression is described as well how it might be integrated into identification drug
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