Optimization of Growth Medium for Efficient Cultivation of Lactobacillus salivarius i 24 using Response Surface Method

摘要: Production of Lactobacillus salivarius i 24, a probiotic strain for chicken, was studied in batch fermentation using 500 mL Erlenmeyer flask. Response surface method (RSM) used to optimize the medium efficient cultivation bacterium. The factors investigated were yeast extract, glucose and initial culture pH. A polynomial regression model with cubic quartic terms analysis experimental data. Estimated optimal conditions growth L. 24 were; 3.32 % (w/v) glucose, 4.31 extract pH 6.10.