Liquid biopsies: tumor diagnosis and treatment monitoring -

摘要: Cancer is a disease with high evolutionary, i.e., malignant, characteristics that change under selective pressure from therapy. Characterization based on molecular or primary tumor properties clinicopathological staging does not fully reflect the state of cancer, especially when cancer cells metastasize. This major reason for failure treatment. Currently, there an urgent need new approaches allow more effective, but less invasive, monitoring status, thereby improving efficacy treatments. With recent technological advances, “liquid biopsies,” isolation intact analysis components are secreted cells, such as nucleic acids exosomes, could be implemented easily. approach would facilitate real-time and accurate measurement critical biomarkers. In this review, we summarize progress in identification circulating using high-resolution discuss acid- exosome-based approaches. The information obtained through liquid biopsies used to gain better understanding cell invasiveness metastatic competence, which then benefit translational applications personalized medicine.