CIRCULATING THYROID-STIMULATING HORMONE RECEPTOR MESSENGER RNA AS A MARKER OF TUMOR AGGRESSIVENESS IN PATIENTS WITH PAPILLARY THYROID MICROCARCINOMA
作者： Altay Aliyev , Manjula Gupta , Christian Nasr , Betul Hatipoglu , Mira Milas
DOI: 10.4158/EP14425.OR
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摘要: ABSTRACT Background: We have previously shown that thyroid-stimulating hormone receptor messenger RNA (TSHR mRNA) is detectable in the peripheral blood of patients with papillary thyroid microcarcinoma (PTmC). The aim this study was to analyze utility TSHR mRNA status as a marker tumor aggressiveness PTmC. Methods: Preoperative values were obtained 152 who underwent thyroidectomy and found PTmC on final pathology. Clinical parameters analyzed from an institutional review board-approved database using χ2 t tests. Results: Preoperatively, detected 46% patients, which less than for macroscopic carcinoma (PTC) (80%) but higher benign disease (18%) (P<.001). focus cancer larger mRNA-positive group compared negative (0.41 vs. 0.30 cm, respectively, P = .015). prevalence tall-cell variant TSHR...
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