Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia
作者： Richard F Schlenk , Konstanze Döhner , Jürgen Krauter , Stefan Fröhling , Andrea Corbacioglu
DOI: 10.1056/NEJMOA074306
关键词:
摘要: Background Mutations occur in several genes cytogenetically normal acute myeloid leukemia (AML) cells: the nucleophosmin gene (NPM1), fms-related tyrosine kinase 3 (FLT3), CCAAT/enhancer binding protein α (CEPBA), myeloid–lymphoid or mixed-lineage (MLL), and neuroblastoma RAS viral oncogene homolog (NRAS). We evaluated associations of these mutations with clinical outcomes patients. Methods compared mutational status NPM1, FLT3, CEBPA, MLL, NRAS cells outcome 872 adults younger than 60 years age AML. Patients had been entered into one four trials therapy for In each study, patients an HLA-matched related donor were assigned to undergo stem-cell transplantation. Results A total 53% NPM1 mutations, 31% FLT3 internal tandem duplications (ITDs), 11% kinase–domain 13% CEBPA 7% MLL partial ...
researchgate.net 
sci-hub.se 参考文章(44)
Daniel G. Tenen, Thomas Pabst, Beatrice U. Mueller, Pu Zhang, Hanna S. Radomska, Sailaja Narravula, Susanne Schnittger, Gerhard Behre, Wolfgang Hiddemann, Dominant-negative mutations of CEBPA , encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia Nature Genetics. ,vol. 27, pp. 263- 270 ,(2001) , 10.1038/85820
Guido Marcucci, Krzysztof Mrózek, Amy S. Ruppert, Kati Maharry, Jonathan E. Kolitz, Joseph O. Moore, Robert J. Mayer, Mark J. Pettenati, Bayard L. Powell, Colin G. Edwards, Lisa J. Sterling, James W. Vardiman, Charles A. Schiffer, Andrew J. Carroll, Richard A. Larson, Clara D. Bloomfield, Prognostic Factors and Outcome of Core Binding Factor Acute Myeloid Leukemia Patients With t(8;21) Differ From Those of Patients With inv(16): A Cancer and Leukemia Group B Study Journal of Clinical Oncology. ,vol. 23, pp. 5705- 5717 ,(2005) , 10.1200/JCO.2005.15.610
Tapani Ruutu, Adam R. Oberkircher, Sakari Knuutila, Krzysztof Mrózek, Erkki Elonen, Geoffrey P. Herzig, Clara D. Bloomfield, Guido Marcucci, Matthew P. Strout, Bayard L. Powell, AnneMarie W. Block, David Lawrence, Diane C. Arthur, Albert de la Chapelle, Feng Yu, P. Nagesh Rao, Charles A. Schiffer, Michael A. Caligiuri, Maria R. Baer, Rearrangement of ALL1 (MLL) in Acute Myeloid Leukemia with Normal Cytogenetics Cancer Research. ,vol. 58, pp. 55- 59 ,(1998)
R.F. Schlenk, A. Benner, J. Krauter, T. Büchner, C. Sauerland, G. Ehninger, M. Schaich, B. Mohr, D. Niederwieser, R. Krahl, R. Pasold, K. Döhner, A. Ganser, H. Döhner, G. Heil, Individual Patient Data–Based Meta-Analysis of Patients Aged 16 to 60 Years With Core Binding Factor Acute Myeloid Leukemia: A Survey of the German Acute Myeloid Leukemia Intergroup Journal of Clinical Oncology. ,vol. 22, pp. 3741- 3750 ,(2004) , 10.1200/JCO.2004.03.012
Stefan Fröhling, Richard F. Schlenk, Ina Stolze, Jörg Bihlmayr, Axel Benner, Sylvia Kreitmeier, Karen Tobis, Hartmut Döhner, Konstanze Döhner, CEBPA Mutations in Younger Adults With Acute Myeloid Leukemia and Normal Cytogenetics: Prognostic Relevance and Analysis of Cooperating Mutations Journal of Clinical Oncology. ,vol. 22, pp. 624- 633 ,(2004) , 10.1200/JCO.2004.06.060
Peter J.M. Valk, Roel G.W. Verhaak, M. Antoinette Beijen, Claudia A.J. Erpelinck, Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, Judith M. Boer, H. Berna Beverloo, Michael J. Moorhouse, Peter J. van der Spek, Bob Löwenberg, Ruud Delwel, Prognostically useful gene-expression profiles in acute myeloid leukemia. The New England Journal of Medicine. ,vol. 350, pp. 1617- 1628 ,(2004) , 10.1056/NEJMOA040465
Krzysztof Mrózek, Hartmut Döhner, Clara D Bloomfield, Influence of new molecular prognostic markers in patients with karyotypically normal acute myeloid leukemia: recent advances. Current Opinion in Hematology. ,vol. 14, pp. 106- 114 ,(2007) , 10.1097/MOH.0B013E32801684C7
Jr. Frank E. Harrell, Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis ,(2010)
Pierre Wijermans, Harry Schouten, Peter C. Huijgens, Hans van der Lelie, Martin Fey, Augustin Ferrant, Johan Maertens, Alois Gratwohl, Bob Lowenberg, Jan J. Cornelissen, Wim L. J. van Putten, Leo F. Verdonck, Matthias Theobald, Emanuel Jacky, Simon M. G. Daenen, Marinus van Marwijk Kooy, Results of a HOVON/SAKK donor versus no-donor analysis of myeloablative HLA-identical sibling stem cell transplantation in first remission acute myeloid leukemia in young and middle-aged adults: benefits for whom? Blood. ,vol. 109, pp. 3658- 3666 ,(2007) , 10.1182/BLOOD-2006-06-025627
Jacques Delaunay, Norbert Vey, Thierry Leblanc, Pierre Fenaux, Françoise Rigal-Huguet, Francis Witz, Thierry Lamy, Anne Auvrignon, Didier Blaise, Arnaud Pigneux, Francine Mugneret, Christian Bastard, Nicole Dastugue, Jacqueline Van den Akker, Denis Fière, Josy Reiffers, Sylvie Castaigne, Guy Leverger, Jean-Luc Harousseau, Hervé Dombret, Prognosis of inv(16)/t(16;16) acute myeloid leukemia (AML): a survey of 110 cases from the French AML Intergroup. Blood. ,vol. 102, pp. 462- 469 ,(2003) , 10.1182/BLOOD-2002-11-3527