Role of HIV-1-specific CD4 T cells.

摘要: PURPOSE OF REVIEW Most of the studies investigating antiviral immunity have predominantly focused on CD8 T cells. However, numerous recent highlighted importance HIV-1-specific CD4 cells in immune response, and also revealed high level complexity heterogeneity virus-specific T-cell responses. An understanding role these key players response is fundamental importance. RECENT FINDINGS A comprehensive investigation several features responses, including magnitude, breadth, function phenotype, has recently been performed. In particular, responses studied different stages HIV-1 infection, i.e. acute chronic phase, under conditions spontaneous (long-term non-progressors) or therapy-mediated control virus replication uncontrolled replication. Different phenotypical functional patterns were associated with controlled versus replication, thus allowing identification signatures protective Robust diverse observed. These however, not predictive nonprogressive progressive HIV-1-associated disease. SUMMARY There an urgent need to delineate correlates order develop novel immunological markers evaluate degree restoration therapy as well potential effectiveness HIV vaccine-induced