Slower CD4 cell decline following cessation of a 3 month course of HAART in primary HIV infection: findings from an observational cohort.

摘要: Objective: To investigate the effect of a short course HAART during primary HIV infection (PHI) on rate CD4 cell and viral load change.Methods: Data following cessation from 89 individuals (seroconverting 1999-2003) who chose to take 3 month at PHI were compared with 179 untreated controls in CASCADE, using linear nonlinear random effects models. Participants non-randomized but frequency matched for age, sex, risk factor, year seroconversion presentation within first 6 months seroconversion. Time count < 350 cells/mu l initiation clinically indicated antiretroviral therapy (ART) also as competing risks.Results: The decline appeared significantly slower among treated participants than controls: losses 51 [95% confidence interval (CI), 32-69] 77cells/mu (95% Cl, 65-89), respectively, years after (P = 0.011). Based extrapolated data, loads differed this point (4.09 4.53 copies/ml, respectively). At 2 years, there was no significant difference mean levels: 4.31 copies/ml 4.14-4.48) 4.47 4.28-4.66), respectively. CASCADE seroconverters more likely reach or initiate ART (hazard ratio, 1.45; 95% 1.02-2.05; P=0.039).Conclusion: A may delay decline. Confirmation requires randomized clinical trial powered address definitively role intervention (currently underway through SPARTAC). (C) 2007 Lippincott Williams & Wilkins.