Antiretroviral therapy initiated during acute HIV infection fails to prevent persistent T cell activation

摘要: Initiation of ART during acute HIV-1 infection may prevent persistent immune activation. We analyzed longitudinal CD38+HLA-DR+ CD8+ T cell percentages in 31 acutely infected individuals who started early (median 43 days since infection) and successful ART, maintained viral suppression through 96 weeks. Pre-therapy a median 72.6% cells were CD38+HLA-DR+, while this decreased to 15.6% by weeks, it remained substantially higher than seronegative controls 8.9%, p=0.008). Shorter time predicted lower activation at These results support the hypothesis that very events pathogenesis result prolonged dysfunction.