Familial gastric cancer: genetic susceptibility, pathology, and implications for management.

摘要: Summary Familial gastric cancer comprises at least three major syndromes: hereditary diffuse cancer, adenocarcinoma and proximal polyposis of the stomach, familial intestinal cancer. The risk development is high in families affected b-y these syndromes, but only genetically explained (caused by germline alterations CDH1 , which encodes E-cadherin). Gastric also associated with a range several cancer-associated syndromes known genetic causes, such as Lynch, Li-Fraumeni, Peutz-Jeghers, breast–ovarian adenomatous polyposis, juvenile polyposis. We present contemporary knowledge on genetics, pathogenesis, clinical features discuss research technological developments, together are expected to open avenues for new testing approaches novel therapeutic strategies.