Effect of zinc and copper deficiency on microsomal NADPH-dependent active oxygen generation in rat lung and liver.

摘要: Both dietary zinc and copper deficiencies can cause lipid peroxidation in microsomes rats. The cytochrome P-450 enzyme system generate active oxygens by uncoupling of the P-450-oxy complex catalytic cycle and/or electron transfer mediated NADPH-cytochrome reductase. effects on NADPH-dependent H2O2 generation, activity with aminopyrine as substrate reductase were determined. Zinc deficiency caused increased production, activity, decreased demethylation two- fivefold increases iron concentration lung liver microsomes, respectively, compared to Zn-adequate, ad libitum--fed controls. Active oxygen generation accumulation are thus possible mechanisms which causes microsomal peroxidation. Copper did not affect production; however, it fourfold Cu-adequate, mechanism cooper is still unknown but could be related observed iron.