Human Genetic Ancestral Composition Correlates with the Origin of Mycobacterium leprae Strains in a Leprosy Endemic Population

摘要: Recent reports have suggested that leprosy originated in Africa, extended to Asia and Europe, arrived the Americas during European colonization African slave trade. Due colonization, contemporary Colombian population is an admixture of Native-American, ancestries. Because microorganisms are known accompany humans migrations, patterns human migration can be traced by examining genomic changes associated microbes. The current study analyzed 118 cases 116 unrelated controls from two regions endemic for (Atlantic Andean) order determine possible associations with patient ancestral background (determined using 36 ancestry informative markers), Mycobacterium leprae genotype and/or geographical origin. We found significant differences between genetic composition. components were predominant Andean populations. In contrast, higher Atlantic region. M. genotypes then cluster compared composition patients. Two principal clusters found: haplotypes C54 T45. Haplotype origin was more frequent patients region a high component. haplotype T45 These results suggest genomes co-existed since origins disease, ultimately arriving Colombia colonization. Distinct strains followed settlement country detected