Combinations of ZAP-70, CD38 and IGHV mutational status as predictors of time to first treatment in CLL
作者： Alison Morilla , David Gonzalez de Castro , Ilaria Del Giudice , Nnenna Osuji , Monica Else
DOI: 10.1080/10428190802360810
关键词:
摘要: ZAP-70, CD38 and IGHV mutations have all been reported to prognostic impact in chronic lymphocytic leukemia (CLL), both individually paired combinations. We aimed determine whether the combination of three factors provided more refined information concerning treatment-free interval (TFI) from diagnosis. were evaluated 142 patients. Combining factors, ZAP-70−/CD38−/Mutated group showed longest median TFI (62 months, n = 37), ZAP-70+/CD38+/Unmutated cases shortest (11 37) discordant for ≥1 factor, an intermediate (27 68) (p 0.006). Analysis revealed values that otherwise masked when measuring single factors. The presence or absence cytogenetic abnormalities did not explain variability among cases. Simultaneous analysis CLL provides discriminatory prediction than any factor alone.
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