High Parathyroid Hormone Level and Osteoporosis Predict Progression of Coronary Artery Calcification in Patients on Dialysis

摘要: Coronary artery calcifications (CACs) are observed in most patients with CKD on dialysis (CKD-5D). CACs frequently progress and associated increased risk for cardiovascular events, the major cause of death these patients. A link between bone vascular calcification has been shown. This prospective study was designed to identify noninvasive tests predicting CAC progression, including measurements mineral density (BMD) novel markers adult CKD-5D. At baseline after 1 year, underwent routine blood measurement CAC, BMD, serum markers. total 213 received measurements, whom about 80% had measurable almost 50% Agatston scores>400, conferring high events. Independent positive predictors included coronary disease, diabetes, vintage, fibroblast growth factor-23 concentration, age, whereas BMD spine measured by quantitative computed tomography an inverse predictor. Hypertension, HDL level, smoking were not Three quarters 122 completing increases at year. factors progression or whole parathyroid hormone level greater than nine times normal value, osteoporosis t scores. Our results confirm a role CKD-associated prevalence progression.