Correlation between consanguineous marriages and age-standardized mortality rate due to breast cancer, an ecologic study.

摘要: To the editor Consanguineous unions are common in several countries. This is associated with increase levels of morbidity and mortality offspring [1–4]. Some studies have shown that consanguinity increased some adverse effects at population level [5–7]. Susceptibility to cancer consanguineous marriages has been studied [8–13]. Parental linked a decreased risk breast [13]. Other studies, however, does not affect susceptibility [10–12]. For countries such as our country, where marriage [14, 15], association between due cancers highly important for public health programs. best knowledge, there no study concerning rate cancer. Therefore, present ecological was done. Since older age groups, will higher crude incidence rate. Age standardization procedure weighted averages age-specific rates used modify standard minimize differences composition given populations when comparing these populations. The purpose this compare groups people from different backgrounds structures. Data about age-standardized (ASMR) (per 100,000 population) (for 2002) gross national income per capita (GNI; international dollars) 2000) were obtained World Health Organization web site ( http://www.who.int). Inbreeding coefficient probability an individual received both alleles pair identical ancestral. mean inbreeding (a) values http://www. consang.net. Selection based on availability all above mentioned variables. Table 1 shows list 62 selected corresponding Logarithmic transformation GNI a, because they had skewed distributions logarithmic transformations brought them closer normal distributions. Partial correlation analysis carried out eliminate possible confounding effect ASMR coefficients. After controlling log10GNI capita, significant negative log10a observed (r = -0.267, df 59, P 0.038). We noted lack reliable data lowincome we stratified according their lowand high-income less than more $10,000, respectively. Statistical showed countries, after yet -0.782, 20, \ 0.001). It might be concluded influences independent country income. Several neonatal, infant, under 5-year mortalities [1, 2, 7]. Taken together, M. Saadat (&) I. Department Biology, College Sciences, Shiraz University, 71454 Shiraz, Iran e-mail: saadat@susc.ac.ir; msaadat41@yahoo.com