Enhancement of left ventricular function by glucose-insulin-potassium infusion in acute myocardial infarction

摘要: Abstract Twenty-eight patients admitted to the hospital with suspected acute myocardial infarction underwent baseline studies within 12 hours of onset symptoms. Patients were then randomized receive control infusion (0.45 percent sodium chloride at 20 ml/hour) (15 patients) or glucoseinsulin-potassium (300 g glucose, 50 units regular insulin, 80 mEq KCl/liter water 1.5 ml/kg per hour) (13 for 48 hours. All received 0.45 2 more days. Coronary arteriograms and left ventriculograms obtained in 26 (93 percent) 28 3 weeks after infarction. Radionuclide ejection fraction improved during glucose-insulin-potassium (49 ± 4 55 5 percent, p During experimental pulmonary arterial end-diastolic pressure decreased group (17 mm Hg, These data suggest that human beings (1) increases global fraction, (2) Increases “infarcted zone” without changing “noninfarcted zone”, (3) decreases end-systolic volumes.