Effects of insulin-glucose infusion on left ventricular function at rest and during dynamic exercise in healthy subjects and noninsulin dependent diabetic patients: a radionuclide ventriculographic study.

摘要: Abstract OBJECTIVES The aim of this study was to evaluate: 1) the effects insulin administration on left ventricular ejection fraction (LVEF) during exercise, and 2) eventual impairment cardiovascular response in noninsulin dependent diabetes mellitus. BACKGROUND Insulin influences system, but its effect function has yet be established. METHODS normal saline (test A) insulin-glucose (insulin = 1.7 mU·kg−1·min−1; glucose 6 mg·kg−1·min−1) B) infusions systolic diastolic functions at rest dynamic exercise were examined by radionuclide ventriculography. Twenty-two noninsulin-dependent diabetic patients 22 gender, age body mass index matched healthy subjects investigated. RESULTS Both groups had scintigraphic parameters exercise. Rest- stress-LVEF as well rest- stress-peak filling rate significantly (p CONCLUSIONS In both humans, induces a very important rise LVEF after submaximal work. However, is lower than nondiabetic subjects. increase exercise-LVEF likely due an enhancement contractility. resistance could justify angioscintigraphic indexes