Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats

作者: D. M. Ouwens , C. Boer , M. Fodor , P. de Galan , R. J. Heine

DOI: 10.1007/S00125-005-1755-X

关键词:

摘要: Aims/hypothesis Diabetic cardiomyopathy (DCM) is common in type 2 diabetes. In DCM, insulin resistance may alter cardiac substrate supply and utilisation leading to changes myocardial metabolism function. rats, exposure excessive alimentary fat, inducing a diabetic phenotype, result functional resembling DCM.

参考文章(50)
Ferdinando Carlo Sasso, Ornella Carbonara, Domenico Cozzolino, Pierfrancesco Rambaldi, Luigi Mansi, Daniele Torella, Sandro Gentile, Salvatore Turco, Roberto Torella, Teresa Salvatore, Effects of insulin-glucose infusion on left ventricular function at rest and during dynamic exercise in healthy subjects and noninsulin dependent diabetic patients: a radionuclide ventriculographic study. Journal of the American College of Cardiology. ,vol. 36, pp. 219- 226 ,(2000) , 10.1016/S0735-1097(00)00717-8
K D Philipson, R Ward, Effects of fatty acids on Na+-Ca2+ exchange and Ca2+ permeability of cardiac sarcolemmal vesicles. Journal of Biological Chemistry. ,vol. 260, pp. 9666- 9671 ,(1985) , 10.1016/S0021-9258(17)39290-6
Christian Korvald, Odd Petter Elvenes, Truls Myrmel, Myocardial substrate metabolism influences left ventricular energetics in vivo. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 278, ,(2000) , 10.1152/AJPHEART.2000.278.4.H1345
Alexandra Kessler, Ingo Uphues, D. Margriet Ouwens, Martin Till, Jürgen Eckel, Diversification of cardiac insulin signaling involves the p85α/β subunits of phosphatidylinositol 3-kinase American Journal of Physiology-endocrinology and Metabolism. ,vol. 280, ,(2001) , 10.1152/AJPENDO.2001.280.1.E65
Ulrich Gergs, Peter Boknik, Igor Buchwalow, Larissa Fabritz, Marek Matus, Isabel Justus, Gabriela Hanske, Wilhelm Schmitz, Joachim Neumann, Overexpression of the catalytic subunit of protein phosphatase 2A impairs cardiac function. Journal of Biological Chemistry. ,vol. 279, pp. 40827- 40834 ,(2004) , 10.1074/JBC.M405770200
Michaela Diamant, Hildo J Lamb, Ymte Groeneveld, Edwin L Endert, Jan W.A Smit, Jeroen J Bax, Johannes A Romijn, Albert de Roos, Jasper K Radder, Diastolic dysfunction is associatedwith altered myocardial metabolism inasymptomatic normotensive patientswith well-controlled type 2 diabetes mellitus Journal of the American College of Cardiology. ,vol. 42, pp. 328- 335 ,(2003) , 10.1016/S0735-1097(03)00625-9
P. Borst, J.A. Loos, E.J. Christ, E.C. Slater, Uncoupling activity of long-chian fatty acids Biochimica et Biophysica Acta. ,vol. 62, pp. 509- 518 ,(1962) , 10.1016/0006-3002(62)90232-9
J. Stamler, O. Vaccaro, J. D. Neaton, D. Wentworth, , Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care. ,vol. 16, pp. 434- 444 ,(1993) , 10.2337/DIACARE.16.2.434
T Myrmel, Triacylglycerol metabolism in hypoxic, glucose-deprived rat cardiomyocytes Journal of Molecular and Cellular Cardiology. ,vol. 24, pp. 855- 868 ,(1992) , 10.1016/0022-2828(92)91099-Q