Targeted modulators of the endogenous cannabinoid system: Future medications to treat addiction disorders and obesity

摘要: The endogenous endocannabinoid system encompasses a family of natural signaling lipids (“endocannabinoids”) functionally related to Δ9-tetrahydrocannabinol, the psychoactive ingredient marijuana (cannabis), along with proteins that modulate endocannabinoids, including enzymes, transporters, and receptors. system’s ubiquitous regulatory actions in health disease underscore its importance mammalian (patho)physiology suggest discrete targets through which it may be modulated for therapeutic gain. Medications based on are an important focus contemporary translational research, particularly respect substance abuse obesity, two prevalent disorders pathogenic component hyperactivity. Pressing care needs have made rational design targeted CB1 cannabinoid-receptor modulators promising route future medications significant impact against psychobehavioral metabolic disturbances having reward-supported appetitive component.