Single-dose actinomycin D: Efficacy in the prophylaxis of postmolar gestational trophoblastic neoplasia in adolescents with high-risk hydatidiform mole

摘要: Abstract Objective. To evaluate the efficacy of a single prophylactic dose actinomycin D (Act-D) in reduction postmolar gestational trophoblastic neoplasia (GTN) adolescents with high-risk hydatidiform mole (Hr-HM). Methods. In retrospective study, 60 Hr-HM were selected from cohort patients disease (GTD) followed at Santa Casa, Porto Alegre, Brasil. Twenty-nine received Act-D time uterine evacuation as chemotherapy (P-chem) (study group) and 31 same risk factors did not P-chem (control group). Patient follow-up was both groups. Each group analyzed for number GTN, morbidity associated reproductive outcomes. Results. Postmolar GTN diagnosed two (6.9%) (95% CI, 0.0–16.1) study 9 (29.0%) 13–45) control group. The used 76% (relative risk=0.24; 95% 0.06–0.99). Adverse effects minor. follow-up, when diagnosed, severity increased, compliance reduced, outcomes after discharge similar. Conclusions. reduced during Hr-HM. Since this regimen may reduce treatment costs, without affecting it can be adopted by any Trophoblastic Disease Center.