Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study

摘要: Abstract Purpose To analyze the relationship between pre-treatment measurements of tumor oxygen tension (pO 2 ) and survival in advanced head neck cancer. Patients methods Eppendorf pO 397 patients from seven centers were analyzed using fraction values ≤2.5mmHg (HP 2.5 ), ≤5mmHg 5 median (mmHg) as descriptors. All had intended curative radiation therapy alone or pre- post-operative radiotherapy radio-chemotherapy according to practice at each center. Results The degree hypoxia varied tumors with an overall =9mmHg (range 0–62mmHg), a HP =19% 0–97%) =38%, 0–100%). By quadratic regression correlated Hb (2 P =0.026, n =357), while did not. above population was only parameter that associated poor (Kaplan Meier analysis, =0.006). In multivariate Cox Proportional Hazards stratified institution by far most statistically significant factor explaining variability survival. After adjusting for , clinical stage, dose surgery hemoglobin concentration not model. prognostic model shows 5-year is almost constant range 0 20%, whereas approaches 0% hypoxic tumors. Conclusion This study provides evidence prognosis