Role of Cancer Treatment in Long-Term Overall and Cardiovascular Mortality After Childhood Cancer
作者： Markhaba Tukenova , Catherine Guibout , Odile Oberlin , Françoise Doyon , Abdeddahir Mousannif
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摘要: Purpose The purpose of this study was to assess the role treatment in long-term overall and cardiovascular mortality after childhood cancer. Patients Methods We studied 4,122 5-year survivors a cancer diagnosed before 1986 France United Kingdom. Information on chemotherapy collected, radiation dose delivered heart estimated for 2,870 patients who had received radiotherapy. Results After 86,453 person-years follow-up (average, 27 years), 603 deaths occurred. standardized ratio (SMR) 8.3-fold higher (95% CI, 7.6-fold 9.0-fold higher) relation general populations Thirty-two died as result diseases (ie, 5.0-fold [95% 3.3-fold 6.7-fold] more than expected). risk dying cardiac (n = 21) significantly individuals cumulative anthracycline greater 360 mg/m2 (relative risk...
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